Peroxidative damage to cardiac mitochondria: cytochrome oxidase and cardiolipin alterations
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چکیده
منابع مشابه
Activation of beef-heart cytochrome c oxidase by cardiolipin and analogues of cardiolipin.
Beef-heart cytochrome c oxidase lacking endogenous lipids can be prepared by cholate-mediated exchange with dimyristoylphosphatidylcholine (Powell, G. L., Knowles, P. F. and Marsh, D. (1985) Biochim. Biophys. Acta 816, 191-194). These preparations retained practically no endogenous cardiolipin (less than 0.19 mol cardiolipin per mol of oxidase) but in Tween 80 they retained unaltered electron t...
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Glock, G. E. & McLean, P. (1954). Biochem. J. 56, 171. Horecker, B. L., Gibbs, M., Klenow, H. & Smyrniotis, P. Z. (1954). J. biol. Chem. 207, 393. Hoskin, F. C. G. (1960). Biochim. biophys. Acta, 40, 309. Jolley, R. L., Cheldelin, V. H. & Newburgh, R. W. (1958). J. biol. Chem. 233, 1289. Kinoshita, J. H. (1957). J. biol. Chem. 228, 247. Krebs, H. A. & Henseleit, K. (1932). Hoppe-Seyl. Z. 210, 3...
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Yeast mitochondria, incubated with radioactive amino acids in a "protein-synthesizing mixture" containing an oxidizable substrate and an ATP regenerating system, have been shown by sodium dodecyl sulfate-polyacrylamide gel electrophoresis to incorporate label into polypeptides equivalent in molecular weight and relative amount ot those made in vivo in the presence of cycloheximide. The ability ...
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When isolated mitochondria which have been labeled with [3H]leucine are solubilized and treated with anti-serum specific for cytochrome c oxidase, labeled polypeptides which correspond to the three largest polypeptides of this enzyme are immunoprecipitated. This indicates that the three largest polypeptides of cytochrome c oxidase which have Mr of 66,000, 39,000, and 23,000 are synthesized by i...
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Direct sequencing of cytochrome oxidase subunit III (coxIII) mRNA with a specific primer confirms RNA editing in sunflower (Helianthus annus) mitochondria. Six instances of mRNA editing could be verified, one of these specific to this species. All the editing events involve C to U transitions in the coxIII mRNA causing codon changes that lead to amino acids better conserved in evolution than th...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1998
ISSN: 0014-5793
DOI: 10.1016/s0014-5793(98)00161-6